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DENVER, CO. - AUGUST 08: Colorado State Patrol investigate a head-on-collision in the HOV lanes near along I-25, north of 58th Ave Friday afternoon, August 08, 2014. The wrong way driver, car on the right, was heading southbound in the HOV lanes, the wrong way when it collided with the car on the left. The driver of the wrong way car and the car that was hoot have both been transported to an arena hospital with unknown injuries. (Photo By Andy Cross / The Denver Post)
DENVER, CO. – AUGUST 08: Colorado State Patrol investigate a head-on-collision in the HOV lanes near along I-25, north of 58th Ave Friday afternoon, August 08, 2014. The wrong way driver, car on the right, was heading southbound in the HOV lanes, the wrong way when it collided with the car on the left. The driver of the wrong way car and the car that was hoot have both been transported to an arena hospital with unknown injuries. (Photo By Andy Cross / The Denver Post)
Denver Post city desk reporter Kieran ...
PUBLISHED: | UPDATED:

A wrong-way, head-on crash, which injured two drivers, shut down lanes of I-25 in Denver near 58th Avenue early Friday afternoon.

The crash happened about 12:40 p.m. and one of the two vehicles involved was heading in the wrong direction of the HOV lane, said Trooper Josh Lewis, a Colorado State Patrol Spokesman.

Both drivers were taken to local hospitals with serious injuries, Lewis said.

The HOV/HOT lane has been closed, along with the left lanes of both northbound and southbound I-25, according to the Colorado Department of Transportation.

All lanes, including the HOV lanes, were reopened by 4:30 p.m.

The cause of the crash remains under investigation, including how the wrong-way vehicle wound up on the highway. During that time of day, the HOV is set for northbound traffic coming out of downtown.

Kieran Nicholson: 303-954-1822, knicholson@denverpost.com or twitter.com/kierannicholson